Journal
LAB ON A CHIP
Volume 19, Issue 13, Pages 2178-2191Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9lc00160c
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Funding
- Ministry of Education [R-397-000-215-112, R-397-000-253-112, R-397-000-298-114]
- Singapore-MIT Alliance for Research and Technology (SMART) [R-722-000-013-592]
- Biomedical Institute for Global Health Research and Technology
- N.1 Institute for Health [R-719-000-100-305]
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Multi-organ perfusion systems offer the unique opportunity to mimic different physiological systemic interactions. However, existing multi-organ culture platforms have limited flexibility in specifying the culture conditions, device architectures, and fluidic connectivity simultaneously. Here, we report a modular microfluidic platform that addresses this limitation by enabling easy conversion of existing microfluidic devices into tissue and fluid control modules with self-aligning magnetic interconnects. This enables a ` stick-nplay' approach to assemble planar perfusion circuits that are amenable to both bioimaging-based and analytical measurements. A myriad of tissue culture and flow control TILE modules were successfully constructed with backward compatibility. Finally, we demonstrate applications in constructing recirculating multi-organ systems to emulate liver-mediated bioactivation of nutraceuticals and prodrugs to modulate their therapeutic efficacies in the context of atherosclerosis and cancer. This platform greatly facilitates the integration of existing organs-on-chip models to provide an intuitive and flexible way for users to configure different multi-organ perfusion systems.
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