Journal
LAB ON A CHIP
Volume 19, Issue 11, Pages 1916-1921Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9lc00108e
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Funding
- BioSensor Technologies unit of AIT Austrian Institute of Technology GmbH (Vienna)
- Medical University Vienna
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We have developed a highly integrated lab-on-a-chip containing embedded electrical microsensors, mu degassers and pneumatically-actuated micropumps to monitor allergic hypersensitivity. Rapid antigen-mediated histamine release (e.g. s to min) and resulting muscle contraction (<30 min) is detected by connecting an immune compartment containing sensitized basophile cells to a vascular co-culture model.
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