Journal
LAB ON A CHIP
Volume 19, Issue 11, Pages 1985-1990Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9lc00174c
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Funding
- CONCERT-Japan Photonic Manufacturing Joint Call (FEASIBLE project)
- European Union [654148]
- [GINOP-2.3.2-15-2016-00001]
- [GINOP-2.3.3-15-2016-00040]
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Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin-streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 x 10(3) molecules per mu m(2).
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