Journal
MEDCHEMCOMM
Volume 10, Issue 6, Pages 896-900Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9md00166b
Keywords
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Funding
- AMED [JP18mk0101120]
- Japan Society for the Promotion of Science (KAKENHI) [18K14880, 17k08385]
- Terumo Foundation for Life Sciences and Arts
- Takeda Science Foundation
- Shorai Foundation for Science and Technology
- Tokyo Biochemical Foundation
- Naito Foundation
- NOVARTIS Foundation (Japan) for the Promotion of Science
- Grants-in-Aid for Scientific Research [17K08385, 18K14880] Funding Source: KAKEN
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Antimicrobial peptides (AMPs) have garnered much attention as novel therapeutic agents against infectious diseases. They exhibit antimicrobial activity through microbial membrane disruption based on their amphipathic properties. In this study, we rationally designed and synthesized a series of novel AMPs Block, Stripe, and Random, and revealed that Stripe exhibits potent antimicrobial activity against Gram-positive and Gram-negative microbes. Moreover, we also demonstrated that Stripe disrupts both Gram-positive and Gram-negative mimetic bacterial membranes. Finally, we investigated the hemolytic activity and cytotoxicity in human blood cells and human cell lines, and found that Stripe exhibited neither. These data indicated that Stripe is a promising antimicrobial reagent that does not display significant cytotoxicity.
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