Journal
DRYING TECHNOLOGY
Volume 34, Issue 7, Pages 830-842Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07373937.2015.1084314
Keywords
Atomization; concentration; inhalable; particle size; scale-up; spray dryer; two-fluid nozzle
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A laboratory spray dryer and a commercial dryer with a production rate 50 times greater, both using two-fluid nozzles, were used to dry the same formulation from organic solvent. Both dryers generated particles of similar size, with tight particle size distributions (span <2), which varied with atomization gas flow rate, liquid flow rate, and solids concentration. Small-scale results with an external mixing nozzle were fitted to a correlation based on literature recommendations. This also fitted well for the commercial dryer with external mixing, and an internal mixing nozzle gave a tighter size distribution. Hence, successful verification at scale has been achieved.
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