PSSM-Suc: Accurately predicting succinylation using position specific scoring matrix into bigram for feature extraction

Post-translational modification (PTM) is a covalent and enzymatic modification of proteins, which contributes to diversify the proteome. Despite many reported PTMs with essential roles in cellular functioning, lysine succinylation has emerged as a subject of particular interest. Because its experimental identification remains a costly and time-consuming process, computational predictors have been recently proposed for tackling this important issue. However, the performance of current predictors is still very limited. In this paper, we propose a new predictor called PSSM-Suc which employs evolutionary information of amino acids for predicting succinylated lysine. residues. Here we described each lysine residue in terms of profile bigrams extracted from position specific scoring matrices. We compared the performance of PSSM-Suc to that of existing predictors using a widely used benchmark dataset. PSSM-Suc showed a significant improvement in performance over state-of-the-art predictors. Its sensitivity, accuracy and Matthews correlation coefficient were 0.8159, 0.8199 and 0.6396, respectively. (C) 2017 Elsevier Ltd. All rights reserved.