Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 413, Issue -, Pages 34-49Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2016.11.008
Keywords
Mathematical model; Viral dynamics; Immunology; Cytotoxic T lymphocyte
Categories
Funding
- Australian Postgraduate Award
- National Health and Medical Research Council (NHMRC) [1078068]
- Natural Sciences and Engineering Research Council of Canada
- York Research Chair program
- NHMRC [CDF1061321, AI1071916]
- Australian Research Council [FT110100250]
- Australian Government Department of Health
- National Health and Medical Research Council of Australia [1078068] Funding Source: NHMRC
- Australian Research Council [FT110100250] Funding Source: Australian Research Council
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The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model explains the experimentally observed shortening of a second infection when cross-reactivity is present, and shows that memory in the cellular adaptive immune response is necessary to protect against a second infection.
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