Journal
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
Volume 80, Issue -, Pages 64-70Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtice.2017.08.006
Keywords
Lycopene; Supercritical anti-solvent precipitation; Chromatographic purification; Ultrasonic-assisted extraction; Micronization; Bitter melon
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Funding
- Ministry of Science and Technology of Taiwan [NSC101-2221-E-005-078-MY3, NSC 102-2622-E-005-019-CC2, NSC101-2218-E-224-003-MY2]
- Taichung Veterans General Hospital
- National Chung Hsing University [TCVGH-NCHU1027615]
- Ministry of Education of Taiwan under the ATU plan
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Bitter melon aril is the tissue surrounding the seeds which turns into bright red when the melon is ripen. The ripe bitter melon aril could be an alternative source of nature lycopene for human consumption if proper extraction, purification, and formulation were applied. Ultrasonic extraction and reverse phase chromatography were employed to isolate and purify lycopene from the arils of bitter gourds. The concentration of lycopene increased from 13.6% in the extract obtained ultrasonically using hexane to 98.1% in the elution fraction that was obtained using an ethanol-to-acetone ratio of five to one. Then, the chromatographic purified lycopene was micronized using supercritical carbon dioxide anti-solvent (SAS) process. Under the best condition of SAS process tested in this study, similar to 97% recovery of lycopene was achieved and the obtained particles were in the sub nanometer range with a flaky morphology. This study successfully proved that column fractionation coupled with SAS is a useful process to produce purified and micronized lycopene extracted from ripe bitter melon aril. (C) 2017 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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