Journal
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
Volume 74, Issue -, Pages 238-245Publisher
ELSEVIER
DOI: 10.1016/j.jtice.2016.07.013
Keywords
Drug delivery system; Multi-responsive controlled release; Polymeric microspheres; Core/shell; Yolk/shell
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Funding
- National Natural Science Foundation of China [20904017]
- Program for New Century Excellent Talents in University [NCET-09-0441]
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Multi-responsive polymeric microspheres have attracted more and more interest as drug delivery system (DDS) for anti-tumor drugs because they could achieve on-demand drug release, triggered by the tumor micro-environment. Here the pH, temperature and reduction multi-stimuli responsive polymeric microspheres were fabricated via distillation-precipitation polymerization technique, with or without the middle hollow layer between their pH and reduction responsive poly(methacrylic acid) (PMAA) cores and temperature sensitive poly(N-isopropylacrylamide) (PNIPAM) shells. The effect of the hollow layer on their drug loading and drug release performance was investigated in detail. It was found that the PMAA/PNIPAM yolk/shell microspheres with hollow layer possessed a higher drug loading capacity, while the PMAA/PNIPAM core/shell microspheres without hollow layer exhibited a better controlled release behavior. This understanding must be helpful on designing intelligent anti-tumor DDS. (C) 2016 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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