Journal
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
Volume 90, Issue -, Pages 44-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtice.2017.11.008
Keywords
Computational fluid dynamics; Breath holding; Deposition; Inhalation treatment
Categories
Funding
- JSPS KAKENHI (Tokyo, Japan) [16K21500]
- Hosokawa Powder Technology Foundation (Osaka, Japan)
- Grants-in-Aid for Scientific Research [16K21500] Funding Source: KAKEN
Ask authors/readers for more resources
The therapeutic effect of dry powder inhaler (DPI) formulations can be enhanced by understanding several factors that control the behavior or deposition of inhaled particles in the airways. Computational fluid dynamics (CFD) simulation was performed to predict the behavior and deposition of DPI formulations using a pulmonary model generated on the basis of computed tomography scans of a subject's airway. The effects of inhalation procedures and characteristics, such as flow rate and breath holding, on particle behavior and deposition in the airways were examined. The rate of airflow in the bifurcation area of bronchi was reduced to under 28.3 L/min because, in general, the diameter of the right bronchus is larger than that of the left bronchus in human bronchi. The region of particle deposition differed depending on the rate of airflow. The number of particles deposited in the bronchi decreased upon performing exhalation without breath holding. The results indicated that the turbulence following breath holding promoted particle deposition in the airways. CFD simulation suggested that breath holding is one of the most important factors for enhancing the therapeutic effect of DPI formulations. (C) 2017 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available