Journal
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volume 8, Issue 1, Pages 61-71Publisher
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2019.02.008
Keywords
Microbiota; Inflammation; Diet; Personalized Medicine
Categories
Funding
- Career Development Award from the Crohn's and Colitis Foundation
- Innovator Award from the Kenneth Rainin Foundation
- Seed Grant from the Brain and Behavior program at Georgia State University
- NIH [DK099071, DK083890]
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The last 15 years have witnessed the emergence of a new field of research that focuses on the roles played by the intestinal microbiota in health and disease. This research field has produced accumulating evidence indicating that dysregulation of host-microbiota interactions contributes to a range of chronic inflammatory diseases, including inflammatory bowel diseases, colorectal cancer, and metabolic syndrome. Although dysregulation of the microbiota can take complex forms, in some cases, specific bacterial species that can drive specific clinical outcomes have been identified. Among the numerous factors influencing the intestinal microbiota composition, diet is a central actor, wherein numerous dietary factors can beneficially or detrimentally impact the host/microbiota relationship. This review will highlight recent literature that has advanced understanding of microbiota-diet-disease interplay, with a central focus on the following question: Are we ready to use intestinal microbiota composition-based personalized dietary interventions to treat chronic inflammatory diseases?
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