4.7 Article

Spiro[pyrrol-benzopyran]-based probe with high asymmetry for chiroptical sensing via circular dichroism

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 52, Pages 7438-7441

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc02946j

Keywords

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Funding

  1. Macao Science and Technology Development Fund [082/2016/A2, 019/2017/AMJ]
  2. University of Macau [MYRG2016-00058-FHS, MYRG2017-00066-FHS]
  3. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
  4. National Natural Science Foundation of China [21707143, 21771177]

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This contribution describes an efficient approach to constructing chiral spiro[pyrrol-benzopyran] (SPP) scaffold with high asymmetry. By combining chiral SPP and the achiral sensing moiety phenothiazine, the target probe P showed unprecedented reaction-based chiroptical sensing towards hypochlorite with switching CD signals.

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