Journal
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Volume 82, Issue 5, Pages 495-508Publisher
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC161220045B
Keywords
carbohydrazones; antibacterial; antifungal; antioxidant activity; isomers
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Funding
- Ministry of Education, Science and Technological development of the Republic of Serbia [172013]
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Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone.
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