Rapid micro-induction of buprenorphine/naloxone for opioid use disorder in an inpatient setting: A case series

Background and Objectives Buprenorphine/naloxone has been shown to be effective in the treatment of opioid use disorder. Due to its pharmacological properties, induction can be challenging, time-consuming, and result in sudden onset of withdrawal symptoms. Methods Retrospective case series (n = 2). Results Two patients with opioid use disorder were successfully started on buprenorphine/naloxone using a rapid micro-induction technique that did not cause precipitated withdrawal or require preceding cessation of other opioids. Discussion and Conclusions These cases provide an alternative method for starting buprenorphine/naloxone that offers unique benefits compared to protocols previously described in the literature. Scientific Significance This method can be used to minimize barriers to opioid agonist therapy. (Am J Addict 2019;28:262-265)