Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 14, Issue 131, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsif.2017.0253
Keywords
direct electron transfer; biofuel cell; biosensor; bioelectrochemistry
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Funding
- Air Force Office of Scientific Research
- USDA-NIFA
- Marie Sklodowska-Curie Individual Fellowship (Global) under the European Commission's Horizon 2020 Framework (project 'Bioelectroammonia') [654836]
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Enzymatic bioelectrocatalysis is being increasingly exploited to better understand oxidoreductase enzymes, to develop minimalistic yet specific biosensor platforms, and to develop alternative energy conversion devices and bioelectrosynthetic devices for the production of energy and/or important chemical commodities. In some cases, these enzymes are able to electronically communicate with an appropriately designed electrode surface without the requirement of an electron mediator to shuttle electrons between the enzyme and electrode. This phenomenon has been termed direct electron transfer or direct bioelectrocatalysis. While many thorough studies have extensively investigated this fascinating feat, it is sometimes difficult to differentiate desirable enzymatic bioelectrocatalysis from electrocatalysis deriving from inactivated enzyme that may have also released its catalytic cofactor. This article will review direct bioelectrocatalysis of several oxidoreductases, with an emphasis on experiments that provide support for direct bioelectrocatalysis versus denatured enzyme or dissociated cofactor. Finally, this review will conclude with a series of proposed control experiments that could be adopted to discern successful direct electronic communication of an enzyme from its denatured counterpart.
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