Journal
RESPIRATORY RESEARCH
Volume 20, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12931-019-1118-7
Keywords
-
Categories
Funding
- Medical Research Council [G0901226]
- GlaxoSmithKline RD [CRT114316]
- Nottingham University
- Royal Brompton
- Harefield NHS Foundation Trust
- NIHR Clinician Scientist Fellowship (NIHR) [CS-2013-13-017]
- British Lung Foundation Chair in Respiratory Research [C17-3]
- Medical Research Council [G0901226] Funding Source: researchfish
- National Institute for Health Research [RP-2017-08-ST2-014] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [RP-2017-08-ST2-014] Funding Source: National Institutes of Health Research (NIHR)
- MRC [G0901226, MR/N005953/1] Funding Source: UKRI
Ask authors/readers for more resources
Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying individuals at-risk of progression. Longitudinal change in markers of ECM synthesis was assessed in 145 newly-diagnosed individuals with IPF.Serum levels of collagen synthesis neoepitopes, PRO-C3 and PRO-C6 (collagen type 3 and 6), were elevated in IPF compared with controls at baseline, and progressive disease versus stable disease during follow up, (PRO-C3 p<0.001; PRO-C6 p=0.029). Assessment of rate of change in neoepitope levels from baseline to 3months (defined as slope to month 3': HIGH slope, slope>0 vs. LOW slope, slope<=0) demonstrated no relationship with mortality for these markers (PRO-C3 (HR 1.62, p=0.080); PINP (HR 0.76, p=0.309); PRO-C6 (HR 1.14, p=0.628)). As previously reported, rising concentrations of collagen degradation markers C1M, C3M, C6M and CRPM were associated with an increased risk of overall mortality (HR=1.84, CI 1.03-3.27, p=0.038, HR=2.44, CI 1.39-4.31, p=0.002; HR=2.19, CI 1.25-3.82, p=0.006; HR=2.13 CI 1.21-3.75, p=0.009 respectively).Elevated levels of PRO-C3 and PRO-C6 associate with IPF disease progression. Collagen synthesis and degradation biomarkers have the potential to enhance clinical trials in IPF and may inform prognostic assessment and therapeutic decision making in the clinic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available