Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 375, Issue -, Pages 430-441Publisher
ELSEVIER
DOI: 10.1016/j.jns.2016.12.044
Keywords
Ischemic optic neuropathy; Neuroprotection; Excitotoxicity; Oxidative stress; Angiogenesis; Neuroinflammation
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Optic neuropathy is a neurodegenerative disease which involves optic nerve injury. It is caused by acute or intermittent insults leading to visual dysfunction. There are number of factors, responsible for optic neuropathy, and the optic nerve axon is affected in all type which causes the loss of retinal ganglion cells. In this review we will highlight various mechanisms involved in the cell loss cascades during axonal degeneration as well as ischemic optic neuropathy. These mechanisms include oxidative stress, excitotoxicity, angiogenesis, neuroinflammation and apoptosis following retinal ischemia. We will also discuss the effect of neuroprotective agents in attenuation of the negative effect of factors involve in the disease occurrence and progression. (C) 2016 Published by Elsevier B.V.
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