Journal
ACS APPLIED NANO MATERIALS
Volume 2, Issue 6, Pages 3728-3734Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.9b00630
Keywords
organic nanoparticles; drug-delivery system; visible light; combination therapy; AIE
Funding
- Department of Science and Technology, Science & Engineering Research Board (DST -SERB) [EMR/2016/005885]
- Department of Science and Technology
- SERB, New Delhi, India
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Light-responsive fluorescent organic nanoparticles (NPs) based on tetraphenylethylene (TPE) have been developed for the release of 4 equiv of chlorambucil (Cbl) and photodynamic therapy (PDT) utilizing aggregation induced-emission (AIE) phenomena. Our newly developed TPE(Cbl)(4) NPs displayed strong fluorescence because of its AIE. Upon exposure to visible light, our TPE(Cbl)(4) NPs simultaneously produced singlet oxygen and uncaged 4 equiv of the anticancer drug in a sequential manner in their aggregated state. On the other hand, the released photoproduct also exhibited PDT activity. In vitro studies showed that TPE(Cbl)(4) NPs exhibited properties like self-tracking, cellular imaging, photoregulated chemo-photodynamic therapy, enhanced anticancer activity, and biocompatibility.
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