Journal
KIDNEY & BLOOD PRESSURE RESEARCH
Volume 44, Issue 3, Pages 287-297Publisher
KARGER
DOI: 10.1159/000499646
Keywords
miR-26a; Kidney disease; Mesangial cell; Regulatory T cell; Podocyte
Funding
- National Key R&D Program of China [2016YFC0902700]
- National Natural Science Foundation [81670651, 31401913, 31470776, 81670621]
- Nature Science Foundation of Zhejiang Province [LY16H050001]
- Zhejiang Qianjiang talents plan [QJD1502027]
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MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate many key biological processes by simultaneously suppressing multiple target genes. Among them, miR-26a, a conserved miRNA among vertebrates, is highly expressed in various tissues. Accumulating evidence demonstrates that miR-26a plays pivotal roles in cellular differentiation, cell growth, apoptosis, and metastasis, thereby participating in the initiation and development of various human diseases, such as metabolic disease and cancer. More recently, miR-26a was found as a versatile regulator of renal biology and disease. miR-26a is intensively involved in the maintenance of podocyte homeostasis and the actin cytoskeleton. It is also able to modulate the homeostasis and function of mesangial cells. In addition, miR-26a affects the expansion of regulatory T cells in the context of ischemia-reperfusion injury and autoimmune diabetes and thus protects the renal system from immune attack. These available data strongly suggest that renal miR-26a possesses critical pathological functions and represents a potential target for renal disease therapies. This review summarizes current knowledge of miR-26a in renal biology and disease, laying the foundation for exploring its previously unknown functions and mechanisms in the renal system.
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