Journal
DRUG METABOLISM REVIEWS
Volume 47, Issue 4, Pages 431-454Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03602532.2015.1115871
Keywords
Bone regeneration; bio-chemical agents delivery; drug therapeutics; bioactive scaffolds; stem cell biology; bone structure; biomaterials
Categories
Funding
- Office of Integrative Activities
- Office Of The Director [1457888] Funding Source: National Science Foundation
Ask authors/readers for more resources
Bone loss and failure of proper bone healing continues to be a significant medical condition in need of solutions that can be implemented successfully both in human and veterinary medicine. This is particularly true when large segmental defects are present, the bone has failed to return to normal form or function, or the healing process is extremely prolonged. Given the inherent complexity of bone tissue - its unique structural, mechanical, and compositional properties, as well as its ability to support various cells - it is difficult to find ideal candidate materials that could be used as the foundation for tissue regeneration from technological platforms. Recently, important developments have been made in the implementation of complex structures built both at the macro- and the nano-level that have been shown to positively impact bone formation and to have the ability to deliver active biological molecules (drugs, growth factors, proteins, cells) for controlled tissue regeneration and the prevention of infection. These materials are diverse, ranging from polymers to ceramics and various composites. This review presents developments in this area with a focus on the role of scaffold structure and chemistry on the biologic processes that influence bone physiology and regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available