Journal
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
Volume 52, Issue -, Pages -Publisher
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0502-2018
Keywords
Oregano; Carbapenemase; Multidrug resistance; Antimicrobial activity
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Funding
- National Council for Scientific and Technological Development [480949/2013-1, 407791/2013-2]
- Support Foundation for the Development of Education, Science and Technology in the State of Mato Grosso do Sul [05/2011, 04/2012]
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Introduction: Plant products are sources for drug development against multidrug resistant bacteria. Methods: The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. Results: Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment. Conclusion: OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
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