Related references
Note: Only part of the references are listed.Genomic Landscape of Colorectal Mucosa and Adenomas
Ester Borras et al.
CANCER PREVENTION RESEARCH (2016)
Organoids as an in vitro model of human development and disease
Aliya Fatehullah et al.
NATURE CELL BIOLOGY (2016)
Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer
Lu Zhang et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
Lukas E. Dow et al.
CELL (2015)
Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
Carlos T. Pineda et al.
CELL (2015)
The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling
Ezgi Kunttas-Tatli et al.
MOLECULAR BIOLOGY OF THE CELL (2015)
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
E. M. Alexandrova et al.
NATURE (2015)
The consensus molecular subtypes of colorectal cancer
Justin Guinney et al.
NATURE MEDICINE (2015)
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
Mami Matano et al.
NATURE MEDICINE (2015)
A novel GSK3-regulated APC: Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction
Mira I. Pronobis et al.
ELIFE (2015)
Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
V. Meniel et al.
ONCOGENE (2015)
Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras
Alexander J. Byun et al.
CANCER LETTERS (2014)
5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway
Dipon Das et al.
DNA REPAIR (2014)
Can we safely target the WNT pathway?
Michael Kahn
NATURE REVIEWS DRUG DISCOVERY (2014)
Animal models of colorectal cancer
Robert L. Johnson et al.
CANCER AND METASTASIS REVIEWS (2013)
Understanding Phenotypic Variation in Rodent Models with Germline Apc Mutations
Maged Zeineldin et al.
CANCER RESEARCH (2013)
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas et al.
NATURE REVIEWS CANCER (2013)
A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas
Sergey I. Nikolaev et al.
CANCER RESEARCH (2012)
Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems
Scott A. Nelson et al.
DISEASE MODELS & MECHANISMS (2012)
Oxidatively damaged DNA and its repair in colon carcinogenesis
Barbara Tudek et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2012)
A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation
Shree Harsha Vijaya Chandra et al.
PLOS ONE (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
Mouse Models of Cancer
Dong-Joo Cheon et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)
Assembly of the Base Excision Repair Complex on Abasic DNA and Role of Adenomatous Polyposis Coli on Its Functional Activity
Aruna S. Jaiswal et al.
BIOCHEMISTRY (2011)
Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress
Mariana G. Brocardo et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)
Microsatellite Instability in Colorectal Cancer
C. Richard Boland et al.
GASTROENTEROLOGY (2010)
Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro
Andres I. Roig et al.
GASTROENTEROLOGY (2010)
Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine
Yingben Xue et al.
MOLECULAR CANCER RESEARCH (2010)
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
Curtis A. Thorne et al.
NATURE CHEMICAL BIOLOGY (2010)
Complete deletion of Apc results in severe polyposis in mice
A. F. Cheung et al.
ONCOGENE (2010)
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih-Min A. Huang et al.
NATURE (2009)
APC and the three-hit hypothesis
S. Segditsas et al.
ONCOGENE (2009)
A novel function of adenomatous polyposis coli (APC) in regulating DNA repair
Aruna S. Jaiswal et al.
CANCER LETTERS (2008)
Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli
A. P. Kouzmenko et al.
ONCOGENE (2008)
Wnt signalling and its impact on development and cancer
Alexandra Klaus et al.
NATURE REVIEWS CANCER (2008)
Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations
Mariana Brocardo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42
Y. Kawasaki et al.
ONCOGENE (2007)
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation
Takao Hinoi et al.
CANCER RESEARCH (2007)
Adenomatous polyposis coli (APC):: a multi-functional tumor suppressor gene
Koji Aoki et al.
JOURNAL OF CELL SCIENCE (2007)
APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice
Christine M. Caldwell et al.
JOURNAL OF CELL BIOLOGY (2007)
Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis
J. Qian et al.
ONCOGENE (2007)
Truncated APC regulates the transcriptional activity of β-catenin in a cell cycle dependent manner
Jean Schneikert et al.
HUMAN MOLECULAR GENETICS (2007)
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
Dina Dikovskaya et al.
JOURNAL OF CELL BIOLOGY (2007)
Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair
Aruna S. Jaiswal et al.
BIOCHEMISTRY (2006)
Wnt signalling and the actin cytoskeleton
T. Akiyama et al.
ONCOGENE (2006)
Cytoskeleton out of the cupboard:: colon cancer and cytoskeletal changes induced by loss of APC
Inke Nathke
NATURE REVIEWS CANCER (2006)
Truncated APC is required for cell proliferation and DNA replication
Jean Schneikert et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes
J Sierra et al.
GENES & DEVELOPMENT (2006)
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
T Fujiwara et al.
NATURE (2005)
APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment
RA Green et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
The APC tumor suppressor promotes transcription-independent apoptosis in vitro
K Steigerwald et al.
MOLECULAR CANCER RESEARCH (2005)
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
W Dai et al.
CANCER RESEARCH (2004)
Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
A Tighe et al.
JOURNAL OF CELL SCIENCE (2004)
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
T Watanabe et al.
DEVELOPMENTAL CELL (2004)
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
OJ Sansom et al.
GENES & DEVELOPMENT (2004)
The APC tumor suppressor binds to C-terminal binding protein to divert nuclear β-catenin from TCF
F Hamada et al.
DEVELOPMENTAL CELL (2004)
Adenomatous polyposis coli proteins and cell adhesion
M Bienz et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC
RA Green et al.
JOURNAL OF CELL BIOLOGY (2003)
Refining the relation between 'first hits' and 'second hits' at the APC locus:: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients
M Crabtree et al.
ONCOGENE (2003)
Mutated APC and Asef are involved in the migration of colorectal tumour cells
Y Kawasaki et al.
NATURE CELL BIOLOGY (2003)
The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway
CD Heinen et al.
GASTROENTEROLOGY (2002)
The ins and outs of APC and β-catenin nuclear transport
BR Henderson et al.
EMBO REPORTS (2002)
The 'just-right' signaling model:: APC somatic mutations are selected based on a specific level of activation of the β-catenin signaling cascade
C Albuquerque et al.
HUMAN MOLECULAR GENETICS (2002)
Identification of a link between the tumour suppressor APC and the kinesin superfamily
T Jimbo et al.
NATURE CELL BIOLOGY (2002)
Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice
AM Carothers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
APC, signal transduction and genetic instability in colorectal cancer
R Fodde et al.
NATURE REVIEWS CANCER (2001)
A role for the Adenomatous Polyposis Coli protein in chromosome segregation
KB Kaplan et al.
NATURE CELL BIOLOGY (2001)
Mutations in the APC tumour suppressor gene cause chromosomal instability
R Fodde et al.
NATURE CELL BIOLOGY (2001)
The ABC of APC
NS Fearnhead et al.
HUMAN MOLECULAR GENETICS (2001)
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation
J Zumbrunn et al.
CURRENT BIOLOGY (2001)
The APC tumour suppressor has a nuclear export function
R Rosin-Arbesfeld et al.
NATURE (2000)
Asef, a link between the tumor suppressor APC and G-protein signaling
Y Kawasaki et al.
SCIENCE (2000)
APC mutations in sporadic colorectal tumors:: A mutational hotspot and interdependence of the two hits
AJ Rowan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
F Ficari et al.
BRITISH JOURNAL OF CANCER (2000)
Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
BR Henderson
NATURE CELL BIOLOGY (2000)
Share Paper
