4.6 Article

Asymmetric kinetic resolution of sulfides for the construction of unsymmetric sulfides and chiral 3,3-disubstituted oxindoles

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 26, Pages 6351-6354

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01065c

Keywords

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Funding

  1. National Natural Science Foundation of China [21535004, 91753111, 21874086, 21602125, 21390411]
  2. Key Research and Development Program of Shandong Province [2018YFJH0502]
  3. Natural Science Foundation of Shandong Province [ZR2016BQ38]
  4. China Postdoctoral Science Foundation [40411585]

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A range of 3,3-disubstituted oxindoles accessed using para-quinone methides derived from isatins with thiols were used for the formation of unsymmetrical disulfides, and 3,3-disubstituted oxindoles with a chiral quaternary carbon center and unsymmetric disulfides could also be directly obtained with high selectivities catalyzed by chiral phosphines in one step.

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