Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 41, Issue 9, Pages 1401-1415Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03639045.2015.1018274
Keywords
Amorphous; crystallization; glass transition; miscibility; polymers; solid dispersion; solubility; stability
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Funding
- Creighton University, Omaha
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Solid dispersion has been a topic of interest in recent years for its potential in improving oral bioavailability, especially for poorly water soluble drugs where dissolution could be the rate-limiting step of oral absorption. Understanding the physical state of the drug and polymers in solid dispersions is essential as it influences both the stability and solubility of these systems. This review emphasizes on the classification of solid dispersions based on the physical states of drug and polymer. Based on this classification, stability aspects such as crystallization tendency, glass transition temperature (T-g), drug polymer miscibility, molecular mobility, etc. and solubility aspects have been discussed. In addition, preparation and characterization methods for binary solid dispersions based on the classification have also been discussed.
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