Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 41, Issue 11, Pages 1824-1828Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03639045.2015.1011166
Keywords
Capsaicin; cocktail; CYP; drug-CAP interaction
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Due to the frequent consumption of capsaicin (CAP) and its current therapeutic application, the correct assessment of this compound is important from a public health standpoint. The purpose of this study was to find out whether CAP affects rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C19, and CYP3A4) by using cocktail probe drugs in vivo. A cocktail solution at a dose of 5mL/kg, which contained phenacetin (15mg/kg), omeprazole (15mg/kg), and midazolam (10mg/kg), was given orally to rats treated for 7d with oral administration of CAP. Blood samples were collected at a series of time-points and the concentrations of probe drugs in plasma were determined by HPLC-MS. The results showed that treatment with multiple doses of CAP had no significant effect on rat CYP1A2. However, CAP had a significant inhibitory effect on CYP2C19 and an inductive effect on CYP3A4. Therefore, caution is needed when CAP is co-administered with some CYP substrates clinically because of potential drug-CAP interactions.
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