Journal
FORENSIC CHEMISTRY
Volume 14, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.forc.2019.100164
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Funding
- National Institute of Justice, Office of Justice Programs, U.S. Department of Justice [2016-DN-BX-K0175]
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The six N-(dimethoxybenzyl)-4-bromo-2,5-dimethoxyphenethylamine regioisomers are potential designer compounds related to the common NBOMe drug N-(2-methoxy)benzyl-4-bromo-2,5-dimethoxyphenethylamine (25B-NBOMe). These six compounds represent the incorporation of one additional methoxy-group into the common NBOMe molecular framework. The compounds were prepared from commercially available precursor materials and their electron ionization mass spectra (EI-MS) are quite similar yielding nearly identical fragment ions. The 2',3'-dimethoxybenzyl regioisomer gave a unique fragment ion of significant abundance in the EI-MS at m/z 136. Baseline gas chromatographic resolution of the six regioisomers was achieved using a midpolarity phase of 50% phenyl and 50% dimethyl polysiloxane and the more crowded dimethoxy substitution patterns eluted first under temperature programming conditions. The EI mass spectra for the TFA-derivatives of these six regioisomers gave a molecular ion of significant abundance at m/z 505/507, unlike the parent compounds. Differentiation and specific identification of all six of the regioisomers was possible based on a combination of different base peak ions (m/z 151 or 242/244), unique fragment ions (m/z 136 and m/z 263), along with differences in the relative abundance of ions at m/z 121 and m/z 91.
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