Journal
THERANOSTICS
Volume 9, Issue 18, Pages 5214-5226Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.33574
Keywords
W-doped TiO2 nanoparticles; second near-infrared (NIR-II) window; multi-model imaging; thermoradiotherapy
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Funding
- National Natural Science Foundation of China [81671782]
- National Key Research and Development Program of China [2017YFA0205304]
- Science and Technology Committee of Shanghai [16JC1400604, 15441905800, 18PJD040]
- Clinical Research Plan of SHDC [16CR3057A]
- Medicine & Engineering Cross Research Foundation of Shanghai Jiao Tong University [YG2017ZD02, YG2017MS24]
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Multifunctional nanomaterials that have integrated diagnostic and therapeutic functions and low toxicity, and can enhance treatment efficacy through combination therapy have drawn tremendous amounts of attention. Herein, a newly developed multifunctional theranostic agent is reported, which is PEGylated W-doped TiO2 (WTO) nanoparticles (NPs) synthesized via a facile organic route, and the results demonstrated strong absorbance of these WTO NPs in the second near-infrared (NIR-II) window due to successful doping with W. These PEGylated WTO NPs can absorb both NIR-II laser and ionizing radiation, rendering them well suited for dual-modal computed tomography/NIR-II photoacoustic imaging and synergistic NIR-II photothermal/radiotherapy of tumors. In addition, the long-term in vivo studies indicated that these PEGylated WTO NPs had no obvious toxicity on mice in vivo, and they can be cleared after a 30-day period. In summary, this multifunctional theranostic agent can absorb both NIR-II laser and ionizing radiation with negligible toxicity and rapid clearance, therefore it has great promise for applications in imaging and therapeutics in biomedicine.
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