Journal
ISCIENCE
Volume 17, Issue -, Pages 217-+Publisher
CELL PRESS
DOI: 10.1016/j.isci.2019.06.034
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Funding
- National Natural Science Foundation of China [21671064]
- Science and Technology Planning Project of Hunan Province [2017RS3031]
- Natural Science Foundation of Hunan Province, China [2019JJ10002]
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Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.
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