Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 28, Pages 4424-4431Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00102f
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Funding
- Australian Research Council Industrial Transformation Research Hubs Scheme [IH130100017]
- Marie Curie Actions under EU FP7 Initial Training Network [SNAL 608184]
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The colonisation of biomaterial surfaces by pathogenic bacteria is a significant issue of concern, particularly in light of the rapid rise of antibiotic resistance. Current strategies are proving ineffective as multi-drug resistant pathogenic bacteria emerge. Recently, it was discovered that surfaces with nanoscale features are capable of physically rupturing bacteria and hence displaying mechano-bactericidal activity. In this study, we investigated the interactions between methicillin- and gentamicin-susceptible and -resistant Staphylococcus aureus strains and nanostructured titanium surfaces, fabricated using a hydrothermal etching process. The nanostructured titanium surfaces proved to be equally effective and highly bactericidal against both the susceptible and resistant S. aureus strains, with killing efficiencies of 80.7% +/- 12.0 and 86.8% +/- 11.6, respectively. The mechano-bactericidal activity of these nanostructured titanium surfaces offers an innovative solution to establish medical device surfaces with antimicrobial activity in the context of increasing antibiotic resistance.
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