Journal
NATURE ELECTRONICS
Volume 2, Issue 8, Pages 351-360Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41928-019-0283-5
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Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP16H01857, JP18H01861, JP19J22073]
- New Energy and Industrial Technology Development Organization (NEDO)
- Center of Innovation Program from Japan Science and Technology Agency (JST)
- Commissioned Research of NICT
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) project of the Japan Agency for Medical Research and Development (AMED)
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Differential amplifiers based on organic thin-film transistors (OTFTs) are attractive for monitoring human vital signs because of their signal amplification and noise elimination capabilities. However, substantial variations in OTFTs lead to the degradation of signal processing performance in circuits and restrict the development of organic differential amplifiers capable of recording weak physiological potentials. Here, we report a 2-mu m-thick ultraflexible organic differential amplifier capable of processing physiological signals with high signal integrity and sensitivity. Our approach uses a circuit design and compensation technique that suppress the mismatch among OTFTs to less than a few percent. This leads to a common-mode noise attenuation factor below -12 dB, even during bending to similar to 50 mu m. Using our flexible amplifier, we monitor electrocardiogram signals, where the power of 60 Hz electrical harmonic noise was reduced similar to 60 times during amplification, yielding electrocardiogram signals with a signal-to-noise ratio of 34 dB.
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