Journal
CRYSTENGCOMM
Volume 21, Issue 28, Pages 4145-4149Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ce00666d
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Funding
- National Natural Science Foundation of China [21673279]
- Youth Innovation Promotion Association of CAS [2012242]
- China Postdoctoral Science Foundation
- CAS [2017LH045]
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Cocrystallisation of two non-steroidal anti-inflammatory drugs, piroxicam and clonixin, yielded eight drug-drug cocrystal solvates. Solvents having a moderate polarity are essential for the formation and stabilization of these crystalline complexes. The pharmaceutically acceptable ethyl acetate solvate demonstrated superior physical stability against hydration.
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