Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 57, Pages 8278-8281Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03689j
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Funding
- SERB [EMR/2017/003218/OC]
- University of Delhi
- UGC
- CSIR
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An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines and benzo[h] isoquinolines from easily accessible ortho-formyl-arylketones and aryl/(het)arylmethanamines has been described. Challenging 3-alkynyl/alkenyl isoquinolines and bis-isoquinolines were easily attained through this developed chemistry, which can be further used for various organic transformations. Operational simplicity, high atom-economy, broad substrate scope, functional group tolerance and applicability towards large scale synthesis are the advantageous features of this developed methodology.
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