Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 146, Issue -, Pages 103-106Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2014.09.006
Keywords
Smoking; BMI; fMRI; Food cues
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Funding
- NIDDK/NIH [DRC P30DK045735, R37-DK 20495]
- NIAAA [RL1AA017539]
- NIDA [PL1-DA024859]
- NIH Roadmap for Medical Research Common Fund [UL1-DE019586, UL1-RR024139]
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Background: Although tobacco-smoking is associated with relatively leaner body mass and smoking cessation with weight gain, the brain mechanisms underlying these relationships are not well understood. Smokers compared to non-smokers have shown diminished neural responses to non-tobacco rewarding stimuli (e.g., monetary rewards), but brain responses to favorite-food cues have not been investigated relative to smoking status. We hypothesized that smokers would exhibit diminished neural responses compared to non-smokers in response to favorite-food cues in motivation-reward and emotion-regulating regions of the brain. Methods: Twenty-three smokers and 23 non-smokers matched based on body mass index (BMI), age, and gender listened to personalized favorite-food cue, stress, and neutral-relaxing audiotapes during fMRI. Results: During favorite-food cue exposure, smokers versus non-smokers exhibited diminished activations in the caudate, putamen, insula, and thalamus. Neural responses during stress and neutral-relaxing conditions were similar across groups. Subjective food-craving ratings were similar across groups. Conclusions: The relatively diminished neural responses to favorite-food cues in smokers may contribute to lower BMI. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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