Journal
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
Volume 11, Issue 6, Pages 385-391Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2017.04.006
Keywords
Salt-induced hypertension; pathogenesis; risk factors
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Essential hypertension is common and is associated with significant morbidity and mortality. However, questions remain as to the exact physiological mechanisms underlying this disease. First, we discuss how essential hypertension may be largely a result of a maladaptation to a high-salt diet and that high blood pressure, rather than being an inactive side effect of high salt intake, may be an adaptive mechanism to improve salt secretion. Next, we explain how any physiological state that reduces urinary sodium concentrating ability may increase an individual's risk for salt-induced hypertension. Finally, we conclude that natriuresis is a crucial criterion for effective long-term pharmacologic treatment of essential hypertension. Copyright (C) 2017 American Society of Hypertension. All rights reserved.
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