Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 29, Issue 3, Pages 566-572Publisher
SPRINGER
DOI: 10.1007/s13361-017-1853-2
Keywords
Cocaine; Oral fluid; Analytical validation; Paper spray ionization
Funding
- CNPq
- FAPEG
- CAPES
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This study proposes a new direct and fast method of analysis employing paper spray mass spectrometry (PS-MS). The paper used in the proposed method was modified with molecularly imprinted polymers (MIP) to create a specific site for cocaine analysis in oral fluid. MIP membrane was successfully synthetized and employed. The developed method showed to be linear in a concentration range from LOQ to 100 ng mL(-1). The experimental value of LOQ obtained was 1 ng mL(-1). The inter-day and intra-day precision and accuracy of the PS-MS method presented values lower than 15%. The total recoveries were also evaluated. The PS-MS method for the analysis of cocaine in oral fluid showed to be very promising and the validation parameters showed a good correlation with the literature.
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