Journal
LEARNING & MEMORY
Volume 26, Issue 7, Pages 191-205Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.048389.118
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Funding
- NIH [R15 NS108259, R01 MH113626, R01 MH102394]
- Max Planck Society
- Behrens-Weise Foundation
- European Research Council [714642]
- PRESTO grant from the Japan Science and Technology Agency [JPMJPR1682]
- European Research Council (ERC) [714642] Funding Source: European Research Council (ERC)
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The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order cortico-thalamo-cortical circuit that supports communication between the medial prefrontal cortex (mPFC) and the hippocampus (HC). RE dysfunction is implicated in several clinical disorders including, but not limited to Alzheimer's disease, schizophrenia, and epilepsy. Here, we review key anatomical and physiological features of the RE based primarily on studies in rodents. We present a conceptual model of RE circuitry within the mPFC-RE-HC system and speculate on the computations RE enables. We review the rapidly growing literature demonstrating that RE is critical to, and its neurons represent, aspects of behavioral tasks that place demands on memory focusing on its role in navigation, spatial working memory, the temporal organization of memory, and executive functions.
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