Journal
PULMONARY CIRCULATION
Volume 9, Issue 3, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2045894019864357
Keywords
extracellular vesicles; pulmonary hypertension; biomarkers; T-cells; endothelial cells
Funding
- Universities of Giessen and Marburg Lung Center (UGMLC)
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It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder.
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