Journal
ANTIOXIDANTS
Volume 8, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/antiox8060166
Keywords
tea; bioactive compounds; polyphenols; EGCG; cardiovascular diseases; mechanisms
Funding
- National Key R&D Program of China [2018YFC1604400]
- Shanghai Basic and Key Program [18JC1410800]
- Shanghai Pujiang Talent Plan [18PJ1404600]
- Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University [Agri-X2017004]
- Key Project of Guangdong Provincial Science and Technology Program [2014B020205002]
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Cardiovascular diseases (CVDs) are critical global public health issues with high morbidity and mortality. Epidemiological studies have revealed that regular tea drinking is inversely associated with the risk of CVDs. Additionally, substantial in vitro and in vivo experimental studies have shown that tea and its bioactive compounds are effective in protecting against CVDs. The relevant mechanisms include reducing blood lipid, alleviating ischemia/reperfusion injury, inhibiting oxidative stress, enhancing endothelial function, attenuating inflammation, and protecting cardiomyocyte function. Moreover, some clinical trials also proved the protective role of tea against CVDs. In order to provide a better understanding of the relationship between tea and CVDs, this review summarizes the effects of tea and its bioactive compounds against CVDs and discusses potential mechanisms of action based on evidence from epidemiological, experimental, and clinical studies.
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