Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 70, Issue 14, Pages 1760-1776Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2017.08.037
Keywords
aspirin; cangrelor; clopidogrel; prasugrel; ticagrelor; vorapaxar
Categories
Funding
- Spanish Ministry of Science and Innovation [PNS 2015-71653-R]
- FEDER funds
- U.K. Medical Research Council
- Amgen
- AstraZeneca
- Bayer AG
- Merck Sharp and Dohme
- Bayer Healthcare
- Boehringer Ingelheim
- Bristol-Myers Squibb
- Daiichi-Sankyo
- Servier
- Boston Scientific
- Merck
- Bayer
- Novartis
- Pfizer
- Sanofi
- Eli Lilly
- Guerbet Medical
- Medtronic
- Cordis
- Stago
- Centocor
- Fondation de France
- INSERM
- Federation Francaise de Cardiologie
- Societe Francaise de Cardiologie
- Celgene
- Daiichi-Sankyo Italia
- Novartis Farma
- GlaxoSmithKline
- Roche Diagnostics International
- PlaqueTec
- Actelion/Idorsia
- Avacta
- Bristol-Myers Squibb/Pfizer
- Thermo Fisher Scientific
- The Medicines Company
- MRC [MC_U137686853, MC_UU_12026/6, MC_UU_12026/5] Funding Source: UKRI
- Medical Research Council [MC_UU_12026/6, MC_UU_12026/5, MC_U137686853] Funding Source: researchfish
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Antiplatelet drugs provide first-line antithrombotic therapy for the management of acute ischemic syndromes (both coronary and cerebrovascular) and for the prevention of their recurrence. Their role in the primary prevention of atherothrombosis remains controversial because of the uncertain balance of the potential benefits and risks when combined with other preventive strategies. The aim of this consensus document is to review the evidence for the efficacy and safety of antiplatelet drugs, and to provide practicing cardiologists with an updated instrument to guide their choice of the most appropriate antiplatelet strategy for the individual patient presenting with different clinical manifestations of coronary atherothrombosis, in light of comorbidities and/or interventional procedures. (C) 2017 by the American College of Cardiology Foundation.
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