Journal
EMERGING INFECTIOUS DISEASES
Volume 25, Issue 8, Pages 1511-1521Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2508.181432
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Bio-Manguinhos/FIOCRUZ
- PROEP/CPqRR/FIOCRUZ
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [444417/2014-1, 458134/2014-7]
- Programa Nacional de Imunizacoes, Secretaria de Vigilancia em Saude-Ministerio da Saude, Brazil [TC 277/2013]
- CNPq
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We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine-specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-gamma+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-gamma+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF-specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.
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