Journal
JOURNAL OF CHEMICAL SCIENCES
Volume 131, Issue 8, Pages -Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-019-1647-0
Keywords
Benzimidazole; benzimidazolium salt; coumarin; cytotoxicity
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Coumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by 1H and 13C NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were tested by [ 3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at 100 mu Magainst both cancer cell lines. Moreover, some compounds performed significant activities at 1 mu M against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers.
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