Journal
BIOMATERIALS SCIENCE
Volume 7, Issue 8, Pages 3138-3142Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm00785g
Keywords
-
Categories
Funding
- NIH [CA224605]
Ask authors/readers for more resources
While highly promising in medicine, gene therapy requires delivery agents to protect and target nucleic acid therapeutics. We developed a plant viral siRNA delivery platform making use of self-assembling cowpea chlorotic mottle virus (CCMV). CCMV was loaded with siRNAs targeting GFP or FOXA1; to further enhance cell uptake and intracellular trafficking, resulting in more efficient gene knockdown, we appended CCMV with a cell penetrating peptide (CPP), specifically M-lycotoxin peptide L17E.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available