Journal
FOOD & FUNCTION
Volume 10, Issue 7, Pages 4350-4360Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo00302a
Keywords
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Funding
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the High Value-added Food Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [116012-3]
- National Research Foundation (NRF) of Korea - Ministry of Science ICT [2017R1E1A1A01074320]
- National Research Foundation of Korea [2017R1E1A1A01074320] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cinnamon is known to have several physiological effects; the effects of Cinnamomum japonicum Sieb. on anti-inflammation and tight junctions were investigated in the cellular intestinal inflammation model. Cinnamon subcritical water extract (CSWE) significantly down-regulated the protein and expression levels of nitrite, prostaglandin E2 (PGE(2)), interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, nuclear factor kappa B (NF-kappa B) activity, and the phosphorylation of the factors of the NF-kappa B pathway. It also significantly decreased the permeability but increased the transepithelial electrical resistance (TEER) value and the protein and expression levels of tight junction proteins (i.e., zonula occludens (ZO)-1, occludin, and claudin-1). Furthermore, cinnamic acid and cinnamaldehyde, the major components of C. japonicum, inhibited the phosphorylation of the NF-kappa B pathway and increased the tight junction protein expression. CSWE from C. japonicum may improve intestinal health by enhancing tight junctions and inhibiting inflammation of the intestines.
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