Journal
ANTIBIOTICS-BASEL
Volume 8, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics8020061
Keywords
biofilms; antimicrobial polymers; materials
Categories
Funding
- Department of Biologic and Materials Sciences and Prosthodontics at University of Michigan School of Dentistry
- Rackham Predoctoral Fellowship from the University of Michigan
- MCube (Cost-e ff ective novel antibiotics to combat multidrug-resistant bacteria) from University of Michigan
- National Institute of Health [U01DE023771]
- National Science Graduate Research Fellowship [DGE-1315231]
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Bacterial biofilms and their associated infections are a continuing problem in the healthcare community. Previous approaches utilizing anti-biofilm coatings suffer from short lifetimes, and their applications are limited to surfaces. In this research, we explored a new approach to biofilm prevention based on the hypothesis that changing planktonic bacteria behavior to result in sub-optimal biofilm formation. The behavior of planktonic Pseudomonas aeruginosa exposed to a cationic polymer was characterized for changes in growth behavior and aggregation behavior, and linked to resulting P. aeruginosa biofilm formation, biomass, viability, and metabolic activity. The incubation of P. aeruginosa planktonic bacteria with a cationic polymer resulted in the aggregation of planktonic bacteria, and a reduction in biofilm development. We propose that cationic polymers may sequester planktonic bacteria away from surfaces, thereby preventing their attachment and suppressing biofilm formation.
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