Journal
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
Volume 14, Issue -, Pages -Publisher
ELSEVIER INC
DOI: 10.1016/j.conctc.2019.100332
Keywords
High-intensity interval training; Lacunar stroke; Risk factors; Secondary prevention
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Funding
- Lions Clubs International Foundation, Denmark
- Toyota-Fonden Denmark
- Foundation of Aase & Ejnar Danielsen
- A.P. Moller and Chastine McKinney Moller Foundation
- Memorial Foundation of C.C Klestrup and wife Henriette Klestrup
- Associations of Danish Physiotherapists
- Foundation of Axel Muusfeldts
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Background: The effects of physical exercise in patients with lacunar stroke, seem promising in secondary prevention and only few studies have investigated the effect of high-intensity interval training in patients with lacunar stroke. This study will be investigating whether high-intensity interval training improves cardiovascular fitness as well as cognitive-and endothelial function and potentially attenuating the risk of recurrent stroke. Methods: A randomized controlled trial evaluating 12 weeks of home-based, high-intensity interval training compared with usual care. The intervention group will be exercising 15 min a day, 5 days a week, for 12 weeks. Outcomes will be evaluated at baseline, three, six and twelve months post-stroke with 'The Graded Cycling Test with Talk Test' as the primary outcome registered as power output in Watts. Additionally, an annually register-based follow-up will be performed for 5 years from date of inclusion with a composite endpoint of cardiovascular disease or death. Secondary outcomes will be: physical activity, endothelial response, mental well-being, cognition, mood, fatigue, stress, and MRI scan. Discussion: This study is going to show if early initiated home-based high-intensity interval training is feasible and effective in patients with lacunar stroke. A self-chosen aerobic exercise modality allows a realistic implementation of practice, together with greater chance of long-term adherence. A limitation of the study is that recruitment bias cannot be ruled out, as there may be a preferential enrolment of patients who are self-motivated to engage in exercise.
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