Journal
ONCOLOGY REVIEWS
Volume 13, Issue 1, Pages 54-64Publisher
FRONTIERS MEDIA SA
DOI: 10.4081/oncol.2019.409
Keywords
Mitochondrial DNA (mtDNA) deletion; 4977-bp mtDNA; cancer
Categories
Funding
- Universiti Sains Malaysia [1001/PPSP/8012218, 1001/PPSP/8012242]
Ask authors/readers for more resources
Mitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The most described mtDNA deletion in various human cancers is called the 4977-bp common deletion (mDNA(4977)) and it has been explored since two decades. In spite of that, its implication in carcinogenesis still unknown and its predictive and prognostic impact remains controversial. This review article provides an overview of some of the cellular and molecular mechanisms underlying mDNA(4977) formation and a detailed summary about mDNA(4977) reported in various types of cancers. The current knowledges of mDNA(4977) as a prognostic and predictive marker are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available