4.7 Article

Novel acceptor-donor-acceptor structured small molecule-based nanoparticles for highly efficient photothermal therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 61, Pages 8967-8970

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04195h

Keywords

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Funding

  1. Jiangsu Provincial Key Research and Development Plan [BE2017741]
  2. Natural Science Foundation of Jiangsu Province [BK20180136, BK20160051]
  3. Jiangsu Provincial Medical Youth Talent [QNRC 2016121]
  4. Nanjing Foundation for Development of Science and Technology [2017sc512031, 201605042]

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Herein, acceptor-donor-acceptor structured small molecule (ITIC) based nanoparticles (NPs) were explored for photothermal therapy application. ITIC NPs show red-shift absorption in the near-infrared region, high photostability, and high photothermal conversion efficiency under laser irradiation, presenting both excellent cancer cell cytotoxicity in vitro and tumor ablation in vivo.

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