Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 4, Pages 1412-1415Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b12234
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Funding
- European Commission
- ERC [ERC-STG-259711]
- Royal Society Wolfson Merit Award
- EPSRC [EP/100548X/1]
- Engineering and Physical Sciences Research Council [1525288, EP/I00548X/1] Funding Source: researchfish
- EPSRC [EP/I00548X/1] Funding Source: UKRI
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The design of an enantioselective Pd(II)-catalyzed C-H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable aziridines in high enantiomeric ratios. The aziridines can be derivatized to afford a range of chiral amine building blocks incorporating motifs readily encountered in pharmaceutically relevant molecules.
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