Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 39, Pages 13592-13595Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b06591
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Funding
- BBRSC [BB/ L015129/1]
- European Union's Horizon Research and Innovation Programme through the Marie Sklodowska-Curie Individual Fellowship RAISED [660757]
- Marie Curie actions FP7 through the Intra-European Marie Curie Fellowship Peptide Osteogel [275433]
- Ph.D. studentship within Biomedicine and Bioengineering in Osteoarthritis
- China Scholarship Council
- Engineering and Physical Sciences Research Council (EPSRC) [EP/K020641/1]
- i-sense EPSRC IRC in Early Warning Sensing Systems for Infectious Diseases [EP/K031953/1]
- ERC Seventh Framework Programme Consolidator Grant Naturale CG [616417]
- Marie Curie Actions (MSCA) [660757] Funding Source: Marie Curie Actions (MSCA)
- BBSRC [BB/L015129/1] Funding Source: UKRI
- EPSRC [EP/K031953/1, EP/K020641/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L015129/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K020641/1, EP/K031953/1] Funding Source: researchfish
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We report the thermodynamically controlled growth of solution-processable and free-standing nanosheets via peptide assembly in two dimensions. By taking advantage of self-sorting between peptide beta-strands and hydrocarbon chains, we have demonstrated the formation of Janus 2D structures with single-layer thickness, which enable a predetermined surface hetero-functionalization. A controlled 2D-to-1D morphological transition was achieved by subtly adjusting the intermolecular forces. These nanosheets provide an ideal substrate for the engineering of guest components (e.g., proteins and nanoparticles), where enhanced enzyme activity was observed. We anticipate that sequence-specific programmed peptides will offer promise as design elements for 2D assemblies with face-selective functionalization.
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