Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 40, Pages 14209-14216Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b07392
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Funding
- Natural Science Foundation of Jiangsu Province of China [BK20140410]
- Nano technology Foundation of Suzhou City of China [ZXG201446]
- National Key Basic Research Program of China [2014CB239203]
- Key Program of Hubei Provence [2015CFA126]
- Innovation Team of Wuhan University [2042017kf0232]
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We report the control of guest release profiles by dialing-in desirable interactions between guest molecules and pores in metal-organic frameworks (MOFs). The interactions can derived by the rate constants that were quantitatively correlated with the type of functional group and its proportion in the porous structure; thus the release of guest molecules can be predicted and programmed. Specifically, three probe molecules (ibuprofen, rhodamine B, and doxorubicin) were studied in a series of robust and mesoporous MOFs with multiple functional groups [MIL-101(Fe)-(NH2)(x), MIL-101(Fe)-(C4H4)(x), and MIL-101(Fe)-(C4H4)(x)(NH2)(1-x)]. The release rate can be adjusted by 32-fold [rhodamine from MIL-101(Fe)-(NH2)(x)], and the time of release peak can be shifted by up to 12 days over a 40-day release period [doxorubicin from MIL-101(Fe)-(C4H4)(x)(NH2)(1-x)], which was not obtained in the physical mixture of the single component MOF counterparts nor in other porous materials. The corelease of two pro-drug molecules (ibuprofen and doxorubicin) was also achieved.
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